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Klucel™ LF Pharma, SDS · TDS*. Klucel™ M CS, Klucel™ M CS has excellent film-forming properties and thickens non-aqueous systems and provide lubricious. Klucel hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release, and film coating. This unique polymer. Klucel hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with Klucel HPC is soluble in many polar organic solvents and in water below.

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The information presented here was acquired by UL from the producer of the product or material or original information provider. Difference in the release of flurbiprofen from solid dispersions with poly ethylene oxide and hydroxypropylcellulose and the interaction between medicine and polymers.

We were able to successfully utilize extrusion process to manufacture immediate release tablet formulations of KPR utilizing Klucel polymers. The thickness and diameter of the tablets was measured using a micrometer.

Tablet Characterization Standard characterization tests were performed on tablets manufactured from extruded material.

Compressibility profiles did not exhibit any difference among extruded formulations. An immiscible amorphous system would exhibit two Tgs whereas a miscible system exhibits a single Tg on a DSC run. We would like to thank Mr. Hardness Evaluation Utilizing Texture Analyzer The classical hardness testing registers force required for a tablet to fail break under applied diametrical force between two anvils. Conventional hardness testing was performed on tablets compressed at same compaction pressure on a tableting press.

Are you a distributor who is interested in being listed here? Ketoprofen KPR is a non-steroidal anti-inflammatory drug commonly used in treatment of pain and inflammation. DSC studies have been employed to characterize miscibility of amorphous systems extensively Leuner C, Dressman J. Formulation studies of a poorly water-soluble drug in solid dispersions to improve bioavailability.


This decrease in melting point temperature can also be attributed to drug—polymer interactions drop A release of The extrusion process converted crystalline KPR to an amorphous form, dispersing the same in a hydrophilic HPC matrix that resulted in increased dissolution rate. Such dispersions or solutions, due to their inherent advantages, have been utilized to increase solubility of poorly soluble drugs 9.

The mechanisms of drug release from solid dispersions in water-soluble polymers. Drug Dev Ind Pharm. Friability testing was performed in a friabilator Roche friabilator.

Extruded systems were also studied similarly to evaluate crystallinity.

Standard characterization tests were performed on tablets manufactured from extruded material. This product is used in a variety of food applications, including whipped toppings, bakery cream fillings, edible nut and candy coatings klycel confectionery glazes.

Samples were mounted on adhesive carbon pads placed on aluminum stubs prior to sputter coating. Conversion to a high-energy amorphous form, being one of them, can also impart enhancement in solubility and hence bioavailability 9 In vitro release profiles tablets from extruded matrices. Tensile strength was calculated from hardness values utilizing the following equation. Its ingredients are globally recognized for performance, quality, and consistency.

ELF polymer, being more plastic, forms a denser compact on ,f compressed, thus slowing down the release due to decreased porosity We assume that there might be klufel localized recrystallization of KPR on contact with the dissolution media, thus, slowing down release.

An optimized tablet formulation lv similar release to a marketed formulation. Author information Article notes Copyright and License information Disclaimer. Ashland is a developer and manufacturer of stabilizers and gums used in the Food, Beverage, and Nutrition industry.

In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hot-melt extrusion.

Klucel® Hydroxypropylcellulose LF

Hence, this phase conversion, if any, can be considered to be solution-mediated and not carrier-mediated. During HME process, molten polymer tends to densify on being pushed through a die, resulting in decreased porosity Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends. The extruded rods were pelletized to yield 1-mm pellets utilizing a pelletizer Type L, Thermoscientific, Stone, UK. Water vapor sorption of hot-melt extruded hydroxypropyl cellulose films: Improving drug solubility for oral delivery using solid dispersions.


Addition of mannitol resulted in a decrease in hardness values.

Klucel® Hydroxypropylcellulose LF by Ashland – Food, Beverage & Nutrition

HME process also aided in enhancing tabletting properties and imparted a plastic character to tablets. The release profiles were compared based on calculated similarity factor values. This densification leads to a delayed disintegration and also decreased surface area. Technologies such as solid dispersions have proven viable and been used extensively due to inherent advantages over other technologies 1. Being nonionic, pH-independent release can be achieved from matrices manufactured from these polymers.

The dissolution profiles were compared utilizing model-independent, f 2 similarity factor values. This article has been cited by other articles in PMC. Extrudates pelletized and filled into capsules exhibited a carrier-dependent release with ELF polymer exhibiting a faster release. Pharmaceutical applications of hot-melt extrusion: Physicochemical characterization and drug-release properties of celecoxib hot-melt extruded glass solutions.

Ritonavir-PEG amorphous solid dispersions: Application of the solid dispersion method to the controlled release of medicine. Gereg of Boehringer Ingelheim Pharmaceuticals for the generous loan of tabletting punches and fixture used in compactibility studies. Thus, a slower release, still in the domain of immediate release, might actually contribute towards increased bioavailability and better stability for SDs.