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THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.

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About project SlidePlayer Terms of Service. Share buttons are a little bit lower. To use this website, you must agree to our Privacy Policyincluding cookie policy. This may be helpful for increasing bioavailability, or also if the drug itself is nonspecific in its action.

Disposition of Chemical Compounds. My presentations Profile Feedback Log out. Prrodrugs Privacy Policy Feedback. If you wish to download it, please recommend it to your friends in any social system. Examples of Prodrkgs Bipartate Prosrugs 5.

OK Is the passage of drug from its site of administration to its site of action through cell membranes. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform.

BillJames on May 10, Examples of Carrier-linked Tripartate Prodrugs.

Enzymes — not just your run of the mill protein! To use this website, you must agree to our Privacy Policyincluding biolrecursor policy.

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To make this website work, we log user data and share it with processors. If you wish to download it, please recommend it to your friends in any social system. The lecturer also mentioned that the drugs could sometimes be serendipitously be discovered in their precursor form from a natural source, which makes it cheaper to produce them by harvesting from the source and be used nioprecursor like that. Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr.

Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. What the body does to the drug? Awesome, that makes a lot prodeugs sense. Auth with social network: Protect a non-specific biological environment from a drug Protect a drug from a orodrugs biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents. Cookies help us provide you a better browsing experience.

Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production. Auth with social network: Methenamine the lower the pH, the faster bilprecursor rate of formaldehyde formed blood pH 7. Sites of Administration Sites of action Cell membrane. Published by Aubrey Johnston Modified over 3 years ago.

Removing substances from the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient. What types of groups are the easiest to cleave from a carrier? Happiness for me is largely a matter of digestion -Lin Yutang.

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Suggest some approaches you may use to overcome the solubility problem 2. Disulfide reduction thiamin tetrahydrofurfuryl disulfide thiamin 3. Another example is bioprecurosr prodrugs may not be susceptible to metabolism in the presystemic passing before entering the target cell, but maybe the drug itself is. What the body does to the drug?

Bioprecursor Prodrugs: Molecular Modification of the Active Principle | BenthamScience

Automatically changes to Flash or non-Flash embed. Examples of Carrier-linked Bipartate Prodrugs 4. Phenyl carbamates are rapidly cleaved by plasma enzymes although simple carbamates are generally too stable to hydrolysis.

Download ppt “Bioprecursor Prodrugs”. Presentation Description Prodrugs, medicinal chemistry. Hioprecursor Activation ganciclovir substrate for DNA polymerase 5.

Examples of Carrier-linked Bipartate Prodrugs 6. About project SlidePlayer Terms of Service.

Bioprecursor Prodrugs

Feedback Privacy Policy Feedback. Know some examples of currently used prodrugs. Why have such prodrugs if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane? Prodrugs to minimize toxicity aspirin anti-inflammatory ester derivative of aspirin a. We think you have liked this presentation. If it were nonspecific, then having the drug administered could cause unwanted side effects or toxicity before even reaching its target.

Epinephrine anti-glaucoma bioprecuursor esterase PowerPoint Presentation: