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Eur J Pediatr. Aug;(8) Epub Jun 4. Periventricular leucomalacia: a review. Blumenthal I(1). Author information: (1)The Royal Oldham. During an 18 month period, preterm infants of 34 weeks’ gestation or less were prospectively examined for periventricular leucomalacia (PVL) by cerebral. Periventricular leucomalacia is the term used to describe cerebral infarctions occurring near the lateral ventricles in neonates. The lesion was first described by.

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The term can be misleading, as there is no softening of the tissue in PVL. Around the foci is generally defined area of other lesions of the brain white matter – the death of prooligodendrocytes, proliferation mikrogliocytes and astrocytes, swelling, bleeding, loss of capillaries, and others the so-called “diffuse component PVL”. It likely occurs as a result of hypoxic-ischemic lesions resulting from impaired perfusion at the watershed leucomalacja, which in leycomalacia infants are located in a periventricular location.

Risk factors in the development of intraventricular haemorrhage in the preterm neonate. Periventricular leukomalacia in children. Development of cerebral palsy after ultrasonographic detection of periventricular cysts in the newborn. Magnetic resonance imaging MRI is much more effective at identifying PVL, but it is unusual for preterm infants to receive an MRI unless they have had a particularly difficult course of development including leucomalaciia or severe infection, or known hypoxic events during or immediately after birth.

Sonography is sensitive for the detection of hemorrhage, periventricular leukomalacia and hydrocephalus.

Periventricular leukomalacia

Researchers have begun to examine the potential of synthetic neuroprotection to minimize the amount of lesioning in patients exposed to ischemic conditions. Preventing or delaying premature birth is considered the most important step in decreasing the risk of PVL.


Images in this article Fig. Vlasyuk first revealed the high incidence of optic radiation lesions and demonstrated that PVL – a persistent process that the old necrosis can join a new, foci of PVL may be at different stages of development.

Thank you for updating your details. Ultrasound appearance of the brain in very preterm infants and neurodevelopmental outcome at 18 months of age. Other ongoing clinical studies are aimed at the prevention and treatment of PVL: Intrauterine hypoxia Infant respiratory distress syndrome Transient tachypnea of the newborn Meconium aspiration syndrome pleural disease Pneumothorax Pneumomediastinum Wilson—Mikity syndrome Bronchopulmonary dysplasia. Perinatal asphyxia Periventricular leukomalacia.

Journal of Child Neurology. Erythema toxicum Sclerema neonatorum. Support Center Support Center. A one-year leucomalacoa study. The extent of signs is strongly dependent on the extent of white matter damage: Those with white matter injury often exhibit “tight coupling” of leg joints all extending or all flexing much longer than other infants premature lsucomalacia full-term. Case 6 Case 6. Abstract During an 18 month period, preterm infants of 34 weeks’ gestation or less were prospectively examined for periventricular leucomalacia PVL by cerebral ultrasound.

Additionally, motor deficits and increased muscle tone are often treated with individualized physical and occupational therapy treatments. Ultrasonographic and neurodevelopmental study in the first year of life. Clinical assessment of gestational age in the newborn infant.

Periventricular leukomalacia – Wikipedia

PVL is overdiagnosed by neuroimaging studies and the other white matter lesions of the brain are underestimated. A rat model that has white matter lesions and experiences seizures has been developed, as well as other rodents used in the study of PVL.


Periventricular leukomalacia PVL is a form of white-matter brain injury, characterized by the necrosis more often coagulation of white matter near the leucomslacia ventricles. Hemorrhagic periventricular leukomalacia in the neonate: Please refer to the article on patterns of neonatal hypoxic—ischemic brain injury for a relation between perinatal brain maturation process and these lesions.

Only recently have newer imaging techniques identified both a diffuse and focal component of white matter damage. Since the original description perriventricular Virchow inmuch progress has leucomalacla made in establishing the underlying cause of this condition.

This article has been cited by other articles in PMC. About Blog Go ad-free. Gray baby syndrome muscle tone Congenital hypertonia Congenital hypotonia.

Central nervous system disorders Neonatology. A relation between size and site of the lesion and type and severity of the handicap was established. Pneumopericardium Persistent fetal circulation. Typically, some abnormal neurological signs such as those previously mentioned are visible by the periventrlcular trimester of pregnancy 28 to 40 weeks after conceptionand definitive signs of cerebral palsy are visible by six to nine months of age.

All treatments administered are in response to secondary pathologies that develop as a consequence of the PVL.

Occasionally, physicians can make the initial observations of extreme stiffness or poor ability to suckle. Log in Sign up. Case 9 Case 9. Periventricular leukomalacia of infancy. Placenta praevia Placental insufficiency Twin-to-twin transfusion syndrome.

Umbilical cord prolapse Nuchal cord Single umbilical artery. In the process of morphogenesis focuses PVL pass through three stages: