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There is insufficient evidence to draw conclusions regarding the efficacy of the other antiamoebic drugs. However, the trials’ methodological. Antiamoebic drugs for treating amoebic colitis (Protocol). Gonzales MLM, Dans LF, Martinez EG. This is a reprint of a Cochrane protocol, prepared and. 1. Bioorg Med Chem Lett. Nov 1;26(21) doi: / Epub Sep

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Diseases caused by protozoal organisms are responsible for significant aantiamoebic and morbidity worldwide. Amoebiasis caused by Entamoeba histolytica is an example of such diseases. In the quest for safe and effective antiamoebic agents, several heterocyclic moieties have been reported, out of which members of the azole family dioxazole, pyrazoline, tetrazole, triazole and thiazolidinone derivatives have attracted wide attention.

This class of heterocyclic compounds have emerged as potential chemotherapeutic agents exhibiting promising antiamoebic activity with a non-cytotoxic nature.

In the present article, some important breakthroughs in this area have been discussed. To get an insight at the supra-molecular level, computational studies like Lipinski’s and DFT studies were carried out.

Recent progress on the discovery of antiamoebic agents.

Potent activity, chemical potential and hardness of the active compounds based on theoretical calculations were explained. We also observed that the LUMO level was mainly distributed over the 2-methyl 5-nitro imidazole ring in most of the active compounds.

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Antiamoebic drugs for treating amoebic colitis | Cochrane

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Recent progress on the discovery of antiamoebic agents.

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